Acetaminophen or Tylenol is the safest over-the-counter medication to get relief from pain and fever. However, researchers are still studying its effects. It acts as an Antipyretic (Fever reducer) and an Analgesic (Pain reliever) and is also available in a generic form with side-effects like nausea, stomach pain, itching, etc.

The exact mechanism of it is unknown but may reduce the Prostaglandins (Chemicals causing swelling and inflammation) production in the brain. It also reduces the arthritis pain without affecting the redness, swelling, and inflammation of the joint. It is a Nonsteroidal active drug which should not exceed ten days as it can damage the liver. Depending upon the trimester, it may not be the right option for relieving the pain.

Note: Do not take more than 2 grams (four 500 mg tablets) of acetaminophen a day. According to the researchers, women consumed it for four weeks, or more showed autism.

Researchers say pregnant women who use acetaminophen products for four weeks or more can increase the risk of Autism and ADHD in the newborn.

Is It Safe?

Taking Tylenol at times is safe to cure mild nausea, fever, chills, etc. than other medications during the trimesters. It helps in relieving the pain and is an effective OTC medication during the period. However, it is always advisable to contact the doctor before taking acetaminophen.

 When to take it?

If the pain does not subside, a doctor may prescribe Tylenol. Remember that it is not a good sign it is advisable to consult a gynecologist about other possible ways to ease the pain without any harmful effects. Ibuprofen (Motrin and Advil) are not safe to use unless the doctor recommends it.

How Much Of It Is Required During Pregnancy?

One should take 325 mg of Tylenol which is the set dosage while 650 mg is a potent prescription for the medicine which should be taken every 4 hours in a day.  Avoid taking an unusual amount of this medicine to prevent the future complications.

According to some studies, the overdosage of it can damage the liver of the fetus and enhance the risk of maternal problems hence the dosage should be limited to 4000 mg in every 24 hours.

Is it safe while Breastfeeding?

It is safe as the amount which enters the breast milk develops only 4% of exposure in an infant which is considered normal. Nevertheless, ask the doctor for more breastfeeding techniques and safer medications.

Brand Names

  • Tylenol
  • pain reliever
  • Infants Feverall
  • Acephen
  • PediaCare single-dose acetaminophen
  • Neopap
  • pain reliever/Little fevers infant fever
  • Tylenol ext
  • Tylenol arthritis pain
  • fever reducer


  • Relieves headaches
  • Reduce temperatures
  • Help in muscle aches, cramps and more.
  • Relieves a migraine after combining with caffeine


  • Rashes
  • Itching
  • Swelling
  • Difficulty breathing or swallowing
  • Hives
  • Red skin
  • Affects adult’s emotions
  • Nausea
  • Loss of appetite
  • Stomach pain
  • A headache
  • Dark urine
  • Jaundice
  • Clay-colored stools

Risk Factors

  • Behavioral Problems: As per a few studies, high doses may cause behavioral problems like attention deficit hyperactivity disorder and hyperkinetic disorders. A child born to mothers who took acetaminophen are prone to get troubled with speaking disabilities.
  • Asthma: More research is to be done if it causes asthma
  • Cryptorchidism: According to some studies exposure to it, especially during the first and the second trimester can cause Cryptorchidism in boys but other studies lacked the evidence.

Note: According to the American Association of Poison Control centers the overdose of this drug can even kill and is the most dangerous over-the-counter medications. Symptoms of overdosage include Fatigue, Nausea, Loss of appetite, Sweating, Unusual bleeding, Bruising, Vomiting, Jaundice, Pain in the upper right part of the stomach and flu.

Who should Stay Away From Tylenol?

  • Allergic
  • Consuming medications for seizures or blood thinning
  • Ever developed a rash after taking it
  • A heavy drinker
  • Children between the age 2-11
  • If one has Phenylketonuria (PKU)

Does It Increases The Risk Of ADHD?

The study under the ‘Pediatrics’ which is a journal of the American Medical Association stated that Tylenol and its affecting properties could slow the development of the brain occurring due to the constant hormonal changes.

According to a research in 1996 and 2002 by the Danish National Birth Cohort, 50 percent of 64,322 children fall under the highest risk of getting hyperactivity disorder as well as HKD (hyperkinetic disorders) after crossing the age seven. Moreover, it also saw the connection between the dosage and the ADHD disorders.

Alternatives to Over-the-Counter Medicine During Pregnancy

  • Aromatherapy or Massage
  • Acupuncture for back pain or alleviating the depression
  • Acupressure, Ginger and Vitamin B6 for morning sickness

The Usage And The Risk Of Autism

Tylenol is associated with developing a high risk of autism and autism spectrum disorder in the fetus.

Risk Of Asthma

One study in New Zealand showed the relation between the medicine and the increased risk of asthma in the babies.

Are Products Combining With Tylenol Safe?

Tylenol PM

The amalgam of benadryl and acetaminophen is the business name for tylenol PM. However, it does not affect the health if taken separately but on the other hand, can cause breathing problems and restricted growth of the fetus after taking the combination of the both.

Tylenol With Codeine

Several forms of codeine (1,2,3 and 4 tylenol) and medicines for reducing the pain may detoriate the health. These drugs occur during the third trimester and are considered under the C category as they may develop the signs of withdrawal and several development issues in the neonatal.

Multi-Symptom Tylenol (Sinus, Cold, Pain of Arthritis Flu, Cough)

These remedies often contain Dextromethorphan, Antihistamines, Expectorants and Guaifenesin which lack ample amount of research on the positive effects thus are unsafe to take while pregnant.

ICD-9 and ICD-10 Codes

  • ICD-9 code is 965.4
  • ICD-10 code is T39.1X1A


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