Serophene for Infertility

Serophene is a medicine which helps in treating infertility in a woman. It helps in developing the process of ovulation regardless of the problems like POS (Polycystic Ovary Syndrome) which may affect the normal ovulation. It can be brought to use for several other medical treatments which are not listed in the guide.

What Is Serophene (Clomiphene)?

Serophene also was known as ‘Clomid’ or ‘Clomiphene’ is among the safest medications having a long track record of 40 years in helping women who are not able to ovulate on their own.

It works similar to Estrogen which helps an egg to develop and release. Serophene has the best effect when taken as a pill for usually five days with day 1 being the first day of the period. Although it has some side-effects, they don’t last for long. However, the long-term use can increase the chances of ovarian cancer hence one should not take it for more than six cycles.

Who Benefits From It?

Serophene is beneficial in 4 groups of patients:

  • One with Amenorrhoea and normal levels of Estrogen
  • Women with Oligomenorrhoea and normal levels of Estrogen
  • Those having periods with ovulation but constant minimum luteal phases like the B.B.T chart showing an increase in the temperatures after ovulation for less than 11 days while low progesterone on day 21
  • Those receiving donor insemination which can be very helpful in regulating ovulation especially if the cycle is a little erratic.


The treatment begins within five days of menstrual bleeding. One has to take a single 50 mg dosage for five days daily regardless of the duration. The ovulation will usually occur in 5-13 days after the last dose.

The dosage may increase until the ovulation completely starts and the dosage reaches 200 mg per day. The average patient will ovulate with a 50-100 mg of the dosage for five days. After the achievement of the process, the treatment continues for six cycles at the same dosage levels.

Note: It is advisable to maintain a B.B.T Chart until the treatment continues.

How Effective Is The Serophene Therapy?

80-90% of people who take it should ovulate, and 55% should get pregnant. The reason for this difference is because of the number of patients who think that a defect in the ovary does not affect infertility. However, those who think it to be the sole cause, their pregnancy rate remains high as the ovulation rate.

Approximately 6% of this therapy will develop multiple pregnancies with twins. The patients are though not at risk of getting a miscarriage. It appears to be lower than for the general population. There is no increase in the incidence of abnormalities either.

Is Any Other Test Or Medication Required In Addition To Clomiphene?

It is worth the effort to repeat the post-coital test for patients taking Serophene, although this test may have been previously standard. It is because clomiphene is an anti-estrogen which may result in the mucus becoming much stickier than usual. The additional administration of a short course of a natural estrogen between the last day of clomiphene and the expected time of ovulation can reverse this effect.

If ovulation does not occur even after taking the maximum dosage of Serophene, or if the luteal phase remains inadequate, human chorionic gonadotrophin (H.C.G.) is also the best option though.

Note: Do not use Serophene while pregnant.

Before Taking This Medicine

One should avoid if allergic to it or have:

  • Abnormal vaginal bleeding
  • An ovarian cyst different from a polycystic ovary syndrome
  • A tumor in the pituitary gland
  • An uncontrollable problem with the thyroid or adrenal gland

The doctor can recommend Endometriosis or Uterine Fibroids to examine the right amount of the usage.

Serophene and Breastfeeding

Clomiphene can pass into breast milk and may harm a nursing baby. It may also slow the breast milk production in some women.

How Should I Take Serophene?

The doctor will perform medical tests and a pelvic exam before each treatment to identify the underlying conditions. Follow all the guidelines on the prescription label while not exceeding the larger or smaller amounts as recommended.

One will ovulate within 5-10 days of taking Serophene. However, to improve the chances more, indulge in having sex while ovulating.

The doctor may test the and record the temperature every morning on a chart to help determine the duration and time of the ovulation. In most cases, it should not exceed the three treatment cycles. However, if the ovulation occurs and one does not get pregnant after three treatment cycles the evaluation for infertility is required further.

What To Avoid While Taking Serophene?

It can cause a blurry vision so be careful while driving or doing anything involving the eye work.

Side-Effects Of Serophene

The common side-effect is the hot flushes which occur in ten percent of women due to its anti-estrogenic effect. Other constant signs include breast discomfort, mild depression, abdominal distension and blurring of the vision. The treatment will nevertheless discontinue if it will cause enlarged ovaries.

Other Side Effects Include:

  • An allergic reaction
  • Swelling in the face, lips, tongue or throat
  • Hives
  • Difficulty in breathing
  • Breast pain or tenderness
  • A headache
  • Breakthrough spotting or bleeding
  • Flushing
  • Ovarian hyperstimulation syndrome (OHSS) which is a life-threatening condition.

Consult a doctor right away on experiencing the following symptoms of OHSS:

  • Bloating or stomach pain
  • Nausea, vomiting, diarrhea
  • Rapid weight gain
  • No urination
  • Pain while breathing
  • Rapid heart rate
  • Shortness of breath

Other Drugs Affecting Serophene

Other medications like prescription and OTC medicines, vitamins and herbal products may interact with Clomiphene. Tell the healthcare provider about all the pills in use.

When To Contact The Doctor

  • Vision problems
  • Pelvic pressure or pain
  • Heavy vaginal bleeding
  • Sensitivity to light

ICD-9 and ICD-10 Codes

ICD-9 code is 965.4

ICD-10 code is


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